Rovi Cosmetics to launch skin whitening and depigmentation ingredient

By Katie Nichol

- Last updated on GMT

Related tags In vitro Melanin

Germany-based Rovi Cosmetics is set to launch its skin whitening and depigmentation ingredient, UniTone, at in-cosmetics in Milan on 29-31 March 2011.

UniTone contains aloesin and a vitamin C derivative and is claimed to inhibit the activity of tyrosinase, an enzyme involved in the production of melanin, as well as reducing the skin‘s intracellular and extracellular melanin content.

UniTone incorporates Rovi Cosmetics’ Ineocell delivery technology, which according to the company’s business development and marketing manager, Sarah Teichmüller, is a cell-targeted delivery system that is positively charged (cationic), while the skin is negatively charged (anionic).

Reduction in melanin content

In in vivo​ tests, subjects pre-tanned their skin by UV irradiation for seven days, and then applied a gel containing 3 per cent UniTone twice a day for 14 days.

After 14 days, the melanin content of the stratum basale was reduced by 95 per cent and the melanin content of the stratum spinosum decreased 96 per cent. A control group that applied a placebo gel did not show any decrease in melanin content.

An in vitro​ test on B16 murin melanoma cells showed that a 0.25 per cent concentration of UniTone inhibited tyrosinase activity by 25 per cent.

Furthermore, an in vitro​ study showed that UniTine decreases the intra- and extracellular melanin content proportionally to its concentration. At 0.5 per cent UniTone, intracellular melanin decreased over 50 per cent, while the extracellular melanin decreased over 40 per cent.

Can be used for targeted or uniform skin lightening

The whitening effect of UniTone is reversible, and the ingredient is ideal for use in emulsions or serums, according to Teichmüller

“In a facial emulsion, ​[UniTone] would lead to a uniform skin lightening as desired in Asia. For the Western regions we would suggest a local application as people usually fight pigmentation disorders. Therefore, we would suggest a roll-on applicator containing a serum,”​ she said.

Related products

show more

Calendula Cellular Elixir: Alchemy in a cell

Calendula Cellular Elixir: Alchemy in a cell

Content provided by Naolys | 11-Jun-2024 | Product Brochure

Get ready to experience a cellular evolution in skincare with InnerLift Calendula's advanced Plant Cell biotechnology.

Exosomes: Passing Trend or Transformative Reality?

Exosomes: Passing Trend or Transformative Reality?

Content provided by Naolys | 23-Feb-2024 | Sponsored Link

Exosomes, microscopic vesicles naturally present in abundance within Plant Cells, have garnered significant attention within the scientific and cosmetic...

Give collagen and your products a boost

Give collagen and your products a boost

Content provided by Lycored SARL | 14-Feb-2024 | White Paper

Lumenato, Lycored’s scientifically supported proprietary wellness extract, gets to work quickly complementing and protecting the structural benefits of...

Follow us

Products

View more

Webinars

Podcast

Beauty 4.0 Podcast