Chinese researchers identify IGF2 in oral mucosa as key factor for ‘scarless wound healing’

By Amanda Lim

- Last updated on GMT

[Getty Images]
[Getty Images]

Related tags Wound healing study

A group of researchers from China have identified Insulin-like Growth Factor 2 (IGF2) in oral mucosa as a key factor in accelerating the process of wound healing without scars.

The oral mucosa is the mucous membrane that lines in the inside of the mouth. Compared to skin wounds, oral wounds can heal faster and without leaving scars.

This made the oral mucosa, “an ideal model for studying scarless wound healing”​, said the researchers from the Zunyi Medical University in China.

“Although there is no difference in the wound healing stages of skin and oral mucosa, the healing rate of oral mucosal wounds is faster than that of skin wounds, and most importantly, without scarring.

“And the re-epithelialisation ability of oral mucosal wounds is better than skin wounds, indicating a stronger proliferation capability of oral mucosal keratinocytes.”

The research team identified gene modules and pathways enriched in the basal state of oral mucosa.

Eight gene groups were found and linked to the healing stages of skin and mouth wounds.

One specific group, M8, was unique to the basal state of oral mucosa and thought to be crucial for the inner mouth’s ability for scarless wound healing.

Furthermore, the study discovered that a specific gene, IGF2, stood out as a potential factor that could help heal skin wounds faster.

In vitro and in vivo experiments validated the efficacy of IGF2 in accelerating wound repair.

One of the key findings of the study was the distinct expression profile of extracellular matrix (ECM) components, growth factors, cytokines, and immune mediators in oral mucosal wounds.

Unlike skin wounds, the study found that oral mucosal wounds tend to exhibit higher expression levels of ECM components. This included hyaluronic acid, tendon protein, and fibronectin.

Furthermore, the ratio of type III collagen to type I collagen and the expression of matrix metalloproteinases (MMPs) to tissue inhibitors of metalloproteinases (TIMPs) were found to be significantly higher in oral mucosal wounds.

The study also highlighted that oral mucosal wounds showed reduced levels of inflammatory cytokines and vascular endothelial growth factor (VEGF).

The researchers believe these findings could potentially have significant implications for the field of wound healing and clinical management of acute and chronic wounds.

“Overall, our data indicate that IGF2 is a key factor in oral mucosal wound healing and benefit to skin wound healing. Ultimately, we identify IGF2 and validate its role in skin wound healing, which providing insights into therapeutic targeting of chronic and non-healing wounds.”


Source: International Wound Journal

Identification of IGF2 promotes skin wound healing by co-expression analysis

Authors: Liu et al.

Related news

Show more

Related products

show more

Exosomes: Passing Trend or Transformative Reality?

Exosomes: Passing Trend or Transformative Reality?

Content provided by Naolys | 23-Feb-2024 | Sponsored Link

Exosomes, microscopic vesicles naturally present in abundance within Plant Cells, have garnered significant attention within the scientific and cosmetic...

Give collagen and your products a boost

Give collagen and your products a boost

Content provided by Lycored SARL | 14-Feb-2024 | White Paper

Lumenato, Lycored’s scientifically supported proprietary wellness extract, gets to work quickly complementing and protecting the structural benefits of...

Follow us


View more



Beauty 4.0 Podcast